- Original Article
- Efficacy of imatinib mesylate-based front-line therapy in pediatric chronic myelogenous leukemia
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Hyun Jin Oh, Mun Sung Cho, Jae Wook Lee, Pil-Sang Jang, Nack-Gyun Chung, Bin Cho, Hack-Ki Kim
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Clin Exp Pediatr. 2013;56(8):343-350. Published online August 27, 2013
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Purpose Despite the established role of imatinib (IM) in chronic myelogenous leukemia (CML) in adults, there are few reports on its efficacy in children. In this study, we compared the outcomes of children with CML before and after the advent of IM-based treatment. MethodsThe study cohort consisted of 52 patients treated for CML at the Department of Pediatrics, The Catholic University of... |
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- Utility of a multiplex reverse transcriptase-polymerase chain reaction assay (HemaVision) in the evaluation of genetic abnormalities in Korean children with acute leukemia: a single institution study
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Hye-Jin Kim, Hyun Jin Oh, Jae Wook Lee, Pil-Sang Jang, Nack-Gyun Chung, Myungshin Kim, Jihyang Lim, Bin Cho, Hack-Ki Kim
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Clin Exp Pediatr. 2013;56(6):247-253. Published online June 21, 2013
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Purpose In children with acute leukemia, bone marrow genetic abnormalities (GA) have prognostic significance, and may be the basis for minimal residual disease monitoring. Since April 2007, we have used a multiplex reverse transcriptase-polymerase chain reaction tool (HemaVision) to detect of GA. MethodsIn this study, we reviewed the results of HemaVision screening in 270 children with acute leukemia, newly diagnosed at The... |
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- Immune reconstitution after allogeneic hematopoietic stem cell transplantation in children: a single institution study of 59 patients
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Hyun O Kim, Hyun Jin Oh, Jae Wook Lee, Pil-Sang Jang, Nack-Gyun Chung, Bin Cho, Hack-Ki Kim
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Clin Exp Pediatr. 2013;56(1):26-31. Published online January 29, 2013
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Purpose Lymphocyte subset recovery is an important factor that determines the success of hematopoietic stem cell transplantation (HSCT). Temporal differences in the recovery of lymphocyte subsets and the factors influencing this recovery are important variables that affect a patient's post-transplant immune reconstitution, and therefore require investigation. MethodsThe time taken to achieve lymphocyte subset recovery and the factors influencing this recovery were investigated... |
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- Evaluation of changes in random blood glucose and body mass index during and after completion of chemotherapy in children with acute lymphoblastic leukemia
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Kyong-Won Bang, Soo Young Seo, Jae Wook Lee, Pil-Sang Jang, Min Ho Jung, Nack-Gyun Chung, Bin Cho, Dae-Chul Jeong, Byung Kyu Suh, Hack-Ki Kim
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Clin Exp Pediatr. 2012;55(4):121-127. Published online April 30, 2012
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Purpose Improved survival of patients with childhood acute lymphoblastic leukemia (ALL) has drawn attention to the potential for late consequences of previous treatments among survivors, including metabolic syndrome. In this study, we evaluated changes in 3 parameters, namely, random blood glucose, body mass index (BMI), and Z score for BMI (Z-BMI), in children with ALL during chemotherapy and after completion of... |
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- Outcome of allogeneic hematopoietic stem cell transplantation for childhood acute lymphoblastic leukemia in second complete remission: a single institution study
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Eun-Jung Lee, Ji Yoon Han, Jae Wook Lee, Pil-Sang Jang, Nack-Gyun Chung, Dae-Chul Jeong, Bin Cho, Hack-Ki Kim
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Clin Exp Pediatr. 2012;55(3):100-106. Published online March 16, 2012
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Purpose The survival rate for childhood acute lymphoblastic leukemia (ALL) has improved significantly. However, overall prognosis for the 20 to 25% of patients who relapse is poor, and allogeneic hematopoietic stem cell transplantation (HSCT) offers the best chance for cure. In this study, we identified significant prognostic variables by analyzing the outcomes of allogeneic HSCT in ALL patients in second complete... |
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- CMV antigenemia following pediatric hematopoietic stem cell transplantation : risk factors and outcomes
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Eun-Young Cho, Young-Shil Park, Dae-Hyung Lee, Ji Kyoung Park, Sangrhim Choi, Sun Young Kim, Pil-Sang Jang, Dong-Gun Lee, Nak-Gyun Chung, Jong Hyun Kim, Dae-Chul Jeong, Bin Cho, Jae Gyun Hur, Jin Han Kang, Hack-Ki Kim
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Clin Exp Pediatr. 2006;49(2):173-180. Published online February 15, 2006
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Purpose : Cytomegalovirus(CMV) infection still remains as a major cause of morbidity and mortality after stem cell transplantation. In this study, we analyzed the results of antigenemia-guided pre- emptive therapy among children with allogeneic hematopoietic stem cell transplantation to determine the incidence and risk factors associated with CMV antigenemia, and evaluated the efficacy of the CMV antigenemia based preemptive therapy.... |
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- Short-term follow up of thyroid function after pediatric hematopoietic stem cell transplantation
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Seon-Ju Lee, Jae-Wook Lee, Dae-Hyoung Lee, Young-Joo Kwon, Young-Shil Park, Hui Sung Hwang, Sun Young Kim, Ji Kyoung Park, Pil-Sang Jang, Min-Ho Jung, Nak-Gyun Chung, Dae-Chul Jeong, Bin Cho, Hack-Ki Kim, Byung-Churl Lee
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Clin Exp Pediatr. 2006;49(11):1211-1215. Published online November 15, 2006
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Purpose : In this study, we analyzed the short term changes of thyroid function, incidence and risk factors of thyroid dysfunction soon after allogeneic hematopoietic stem cell transplantation (HSCT) in children.
Methods : We enrolled 80 pediatric patients following allogeneic HSCT, at the Catholic HSCT center between January, 2004 and February, 2006. Serum TSH (thyroid stimulating hormone), total serum thyroxine and... |
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- Erratum
- A Case of Duplication 9p Syndrome(Partial Trisomy 9p)
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Me Gyoung Lee, Young-Nae Roh, Young-Hoon Kim, Chung Sun Baek, Me Gyoung Sin, Jin Lee, Pil-Sang Jang, Jin-Tack Kim, Kweon-Haeng Lee, Kyung-Tai Whang
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Accepted January 1, 1970
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Trisomy 9p syndrome was first described by Rethore, et al in 1970 and about 150 cases have been reported. Trisomy 9p has been reported as either partial or complete. The term "duplication 9p syndrome" instead of "trisomy 9p syndrome" is used since most of the reported patients had only partial duplication rather than the whole arm duplication of 9p. Duplication... |
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